Heart and circulation
What the British Heart Foundation, HEART UK and NICE say about fish oil, CoQ10, garlic, plant sterols, red yeast rice and other supplements sold for the heart.
The British Heart Foundation says research shows supplements do not stop heart and circulatory diseases. NICE finds no evidence that omega-3 compounds lower the risk of cardiovascular disease, except one prescription medicine, and advises doctors not to offer calcium, magnesium or potassium supplements to lower blood pressure. Several supplements, including vitamin K, omega-3 and garlic, can interact with heart medicines such as warfarin. Below is what each source says, with links to read each in full.
BHF: Talk to your doctor before spending money on supplements. If you need them, they will prescribe or recommend them.
Each line below is a short summary of what the named source says, with a link to read it in full. None of it is medical advice.
Advised
Vitamin D
A vitamin the body makes when skin is in sunlight. Oily fish, eggs and fortified foods have some; supplements come as D3 or D2.
- NHS: Everyone should consider 10 micrograms a day in autumn and winter.
Also covered by BHF (Vitamins and supplements to avoid with heart medicines; Do I need supplements for better heart health?).
Limited evidence
Garlic
Garlic made into capsules, powder or extract, often from aged or black garlic.
- BHF: Evidence for garlic supplements is too limited and inconsistent.
Also covered by BHF (7 natural alternatives to statins that claim to lower cholesterol; Vitamins and supplements to avoid with heart medicines).
Omega-3 and fish oil
Fats found in oily fish, and in some plant oils, nuts and seeds; supplements come from fish, krill or algae.
- NICE: No evidence that omega-3 compounds lower cardiovascular disease risk, except one prescription medicine.
Also covered by BHF (Omega-3 foods and your heart; Vitamins and supplements to avoid with heart medicines; 7 natural alternatives to statins that claim to lower cholesterol) and HEART UK.
No good evidence
CoQ10
A vitamin-like substance found in every cell of the body, which the body makes; small amounts are in meat, fish and nuts.
Advised against
Plant sterol and stanol supplements
Plant compounds similar in structure to cholesterol, found in small amounts in nuts, seeds, grains and vegetable oils, and sold as capsules or added to some foods.
- NICE: Do not advise taking plant stanols or sterols to lower cardiovascular disease risk.
- HEART UK: Not recommended as supplements for high cholesterol; not to be confused with fortified foods.
Also covered by BHF.
Potassium
A mineral found in most foods, including fruit, vegetables, beans, nuts, fish and meat.
- NICE: Do not offer potassium supplements as a way of lowering blood pressure.
- BHF: Generally not recommended unless prescribed, especially for older people, kidney disease or heart failure.
Also covered by NHS.
Things to check
- BHF: Vitamin K, omega-3 and St John's wort all interact with the blood-thinning drug warfarin.
- BHF: Garlic supplements can interact with blood thinners such as warfarin; check with your GP first.
- BHF: With blood pressure medicines, garlic supplements could lower blood pressure more than intended.
- BHF: CoQ10 supplements may interact with blood pressure medicines and with warfarin.
- NICE: Some foods, such as grapefruit juice, and some supplements may interfere with statins; ask a pharmacist first.
- BHF: Avoid multivitamins that mix antioxidant vitamins such as A, E and beta-carotene; research links them to a raised risk of death.
- HEART UK: Do not choose fish liver oils: they contain less omega-3 than fish oils and too much vitamin A.
- NHS: Do not take more than 100 micrograms (4,000 IU) of vitamin D a day.
If you take medication, are pregnant, or have a health condition, check with a pharmacist or GP first.
Sources
- Do I need supplements for better heart health?Whether supplements are needed for the heart, which to avoid, and the vitamin D exception.
- Vitamins and supplements to avoid with heart medicinesSupplements that interact with blood pressure medicines, blood thinners and statins, and UK guidance on them.
- Omega-3 foods and your heartOmega-3 fats, the foods they come from, and whether to take a supplement.
- CoQ10 supplements: are there benefits for heart health?CoQ10 with statins and in heart failure, UK guidance, side effects and interactions.
- Is garlic good for you?The evidence on garlic and garlic supplements, and their interactions with medicines.
- 7 natural alternatives to statins that claim to lower cholesterolThe evidence on plant sterols, garlic, omega-3, red yeast rice and other products sold for cholesterol.
- Can potassium-rich foods lower blood pressure?How much potassium people need, food sources, and whether to take a potassium supplement.
- HEART UK Position Statement on ESC/EAS Focused Update on Dietary SupplementsHEART UK's position on dietary supplements for high cholesterol, and plant sterol and stanol products.
- Omega 3 fatsOmega-3 fats, the foods they come from, and HEART UK's advice on supplements.
- Cardiovascular disease: risk assessment and reduction, including lipid modification (NG238), recommendationsThe national guideline on lowering heart and circulatory disease risk, including what not to offer.
- Hypertension in adults: diagnosis and management (NG136), recommendationsThe national guideline on high blood pressure, including lifestyle advice and supplements.
- Vitamin DWho should consider a vitamin D supplement, how much, and the most to take in a day.
- Vitamin KWhere vitamin K comes from, how much adults need, and how much is safe to take.
- Vitamins and minerals - OthersOther vitamins and minerals, including magnesium and potassium: sources, how much people need, and safe amounts.
- WarfarinTaking warfarin, including the medicines, supplements and foods that affect it.
- Advising on complementary products and conventional medicinesGuidance for health professionals on complementary products taken alongside medicines.
Sources checked 28 September 2026. Prices checked 20 October 2026, ranked purely by price per dose. Which sources these pages use.